Probenecid and Ketorolac Nasal Spray: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Probenecid
No brand names on recordKetorolac Nasal Spray
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased ketorolac exposure
Interaction Deep Dive
The concomitant use of ketorolac with probenecid is contraindicated as it may increase the exposure of ketorolac21. The coadministration of oral ketorolac with probenecid resulted in an increase in ketorolac AUC (from 5.4 to 17.8 mcg/hour/mL) and terminal half-life (from 6.6 to 15.1 hours), and a decrease in renal clearance and volume of distribution of ketorolac 1.
Why it happens (mechanism)
Reduced ketorolac clearance
Literature reports
1 report — tap to read
a) The coadministration of oral ketorolac with probenecid resulted in an increase in ketorolac AUC (from 5.4 to 17.8 mcg/hour/mL) and terminal half-life (from 6.6 to 15.1 hours), and a decrease in renal clearance and volume of distribution of ketorolac 1.
Common questions
Can I take Probenecid and Ketorolac Nasal Spray together?
Increased ketorolac exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Probenecid and Ketorolac Nasal Spray interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Probenecid or Ketorolac Nasal Spray need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: SPRIX(R) nasal spray, ketorolac tromethamine nasal spray. American Regent, Inc. (per FDA), Shirley, NY, 2014. DailyMed
- Product Information: ORLYNVAH(TM) oral tablets, sulopenem etzadroxil and probenecid oral tablets. Iterum Therapeutics U.S. Limited (per FDA), Chicago, IL, 2024. DailyMed
Keep reading about Probenecid
Keep reading about Ketorolac Nasal Spray
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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