Ketorolac Nasal Spray

246 interactions 464 cited references

Also sold as: Sprix Sprix®

About Ketorolac Nasal Spray

Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Etodolac Fepradinol Etofenamate Etoricoxib Felbinac Fenoprofen

64 Contraindicated 129 Major 53 Moderate

All (246) Contraindicated (64) Major (129) Moderate (53)

Contraindicated

Ketorolac Nasal Spray Aceclofenac Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Acemetacin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Amtolmetin Guacil Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Aspirin Acuprin® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding, and/or perforation) and possible increase in... Details Ketorolac Nasal Spray Bromfenac Bromsite Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Bufexamac Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Celecoxib Celebrex Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Choline Salicylate Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Clonixin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Dexibuprofen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Dexketoprofen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Diclofenac Aleve Arthritis Pain Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Diflunisal Dolobid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Dipyrone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Droxicam Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Etodolac Lodine Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Etofenamate Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Etoricoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Felbinac Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Fenoprofen Fenopron Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Fepradinol Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Feprazone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Floctafenine Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Flufenamic Acid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Flurbiprofen Ansaid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Ibuprofen Addaprin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Indomethacin Indocin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Ketoprofen Actron® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Lornoxicam Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Loxoprofen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Lumiracoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Meclofenamate Meclodium® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Mefenamic Acid Ponstel® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Meloxicam Alloxate Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Morniflumate Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Nabumetone Relafen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Naproxen Aleve Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Nepafenac Ilevro Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Niflumic Acid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Nimesulide Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

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