Ketorolac Nasal Spray

246 interactions 464 cited references

Also sold as: Sprix Sprix®

About Ketorolac Nasal Spray

Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Etodolac Fepradinol Etofenamate Etoricoxib Felbinac Fenoprofen

64 Contraindicated 129 Major 53 Moderate

All (246) Contraindicated (64) Major (129) Moderate (53)

Contraindicated

Ketorolac Nasal Spray Nimesulide Beta Cyclodextrin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Oxaprozin Coxanto Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Oxyphenbutazone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Parecoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Pentoxifylline Pentoxil® An increased risk of bleeding Details Ketorolac Nasal Spray Phenylbutazone Equi-Phar Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Piketoprofen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Piroxicam Feldene Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Probenecid Increased ketorolac exposure Details Ketorolac Nasal Spray Proglumetacin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Propyphenazone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Proquazone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Rofecoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Salicylic Acid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Salsalate Disalcid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Sodium Salicylate Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Sulfasalazine Azulfidine Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Sulindac Clinoril® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Sulopenem Increased ketorolac tromethamine exposure Details Ketorolac Nasal Spray Tenoxicam Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Tiaprofenic Acid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Tolfenamic Acid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Tolmetin Tolectin 600 Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Nasal Spray Valdecoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Ketorolac Nasal Spray Abciximab An increased risk of bleeding Details Ketorolac Nasal Spray Acenocoumarol An increased risk of bleeding Details Ketorolac Nasal Spray Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Nasal Spray Amineptine An increased risk of bleeding Details Ketorolac Nasal Spray Amitriptyline Elavil An increased risk of bleeding Details Ketorolac Nasal Spray Amitriptylinoxide An increased risk of bleeding Details Ketorolac Nasal Spray Amoxapine An increased risk of bleeding Details Ketorolac Nasal Spray Anagrelide Agrylin An increased risk of bleeding Details Ketorolac Nasal Spray Apixaban Eliquis An increased risk of bleeding Details Ketorolac Nasal Spray Ardeparin An increased risk of bleeding Details Ketorolac Nasal Spray Argatroban An increased risk of bleeding Details Ketorolac Nasal Spray Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Bemiparin An increased risk of bleeding Details Ketorolac Nasal Spray Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Betrixaban Bevyxxa® An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.