Ketorolac Nasal Spray

246 interactions 464 cited references

Also sold as: Sprix Sprix®

About Ketorolac Nasal Spray

Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Etodolac Fepradinol Etofenamate Etoricoxib Felbinac Fenoprofen

64 Contraindicated 129 Major 53 Moderate

All (246) Contraindicated (64) Major (129) Moderate (53)

Major

Ketorolac Nasal Spray Bivalirudin Angiomax An increased risk of bleeding Details Ketorolac Nasal Spray Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Cangrelor Kengreal An increased risk of bleeding Details Ketorolac Nasal Spray Certoparin An increased risk of bleeding Details Ketorolac Nasal Spray Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Cilostazol Pletal® An increased risk of bleeding Details Ketorolac Nasal Spray Citalopram Celexa An increased risk of bleeding Details Ketorolac Nasal Spray Clomipramine Anafranil An increased risk of bleeding Details Ketorolac Nasal Spray Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Clopidogrel Plavix An increased risk of bleeding Details Ketorolac Nasal Spray Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Ketorolac Nasal Spray Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Dabigatran Etexilate An increased risk of bleeding Details Ketorolac Nasal Spray Dalteparin Fragmin An increased risk of bleeding Details Ketorolac Nasal Spray Danaparoid An increased risk of bleeding Details Ketorolac Nasal Spray Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Desipramine Norpramin An increased risk of bleeding Details Ketorolac Nasal Spray Desirudin Iprivask An increased risk of bleeding Details Ketorolac Nasal Spray Desvenlafaxine Pristiq An increased risk of bleeding Details Ketorolac Nasal Spray Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Dibenzepin An increased risk of bleeding Details Ketorolac Nasal Spray Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Ketorolac Nasal Spray Dipyridamole Permole® An increased risk of bleeding Details Ketorolac Nasal Spray Dothiepin An increased risk of bleeding Details Ketorolac Nasal Spray Doxepin Prudoxin An increased risk of bleeding Details Ketorolac Nasal Spray Duloxetine An increased risk of bleeding Details Ketorolac Nasal Spray Edoxaban Savaysa An increased risk of bleeding Details Ketorolac Nasal Spray Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Ketorolac Nasal Spray Enoxaparin Lovenox An increased risk of bleeding Details Ketorolac Nasal Spray Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Nasal Spray Epoprostenol Flolan An increased risk of bleeding Details Ketorolac Nasal Spray Eptifibatide An increased risk of bleeding Details Ketorolac Nasal Spray Escitalopram Lexapro An increased risk of bleeding Details Ketorolac Nasal Spray Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.