Ketorolac Nasal Spray

246 interactions 464 cited references

Also sold as: Sprix Sprix®

About Ketorolac Nasal Spray

Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Etodolac Fepradinol Etofenamate Etoricoxib Felbinac Fenoprofen

64 Contraindicated 129 Major 53 Moderate

All (246) Contraindicated (64) Major (129) Moderate (53)

Major

Ketorolac Nasal Spray Fluoxetine RECONCILE An increased risk of bleeding Details Ketorolac Nasal Spray Fluvoxamine An increased risk of bleeding Details Ketorolac Nasal Spray Fondaparinux Arixtra An increased risk of bleeding Details Ketorolac Nasal Spray Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Gossypol Increased risk of adverse gastrointestinal effects Details Ketorolac Nasal Spray Heparin An increased risk of bleeding Details Ketorolac Nasal Spray Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Iloprost Aurlumyn An increased risk of bleeding Details Ketorolac Nasal Spray Imipramine An increased risk of bleeding Details Ketorolac Nasal Spray Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Inotersen Increased risk of bleeding Details Ketorolac Nasal Spray Lepirudin An increased risk of bleeding Details Ketorolac Nasal Spray Levomilnacipran An increased risk of bleeding Details Ketorolac Nasal Spray Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Ketorolac Nasal Spray Lofepramine An increased risk of bleeding Details Ketorolac Nasal Spray Meadowsweet Increased risk of bleeding Details Ketorolac Nasal Spray Melitracen An increased risk of bleeding Details Ketorolac Nasal Spray Melphalan Alkeran An increased risk of bleeding Details Ketorolac Nasal Spray Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ketorolac Nasal Spray Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Milnacipran Savella An increased risk of bleeding Details Ketorolac Nasal Spray Nadroparin An increased risk of bleeding Details Ketorolac Nasal Spray Nefazodone An increased risk of bleeding Details Ketorolac Nasal Spray Nortriptyline An increased risk of bleeding Details Ketorolac Nasal Spray Opipramol An increased risk of bleeding Details Ketorolac Nasal Spray Parnaparin An increased risk of bleeding Details Ketorolac Nasal Spray Paroxetine Paxil An increased risk of bleeding Details Ketorolac Nasal Spray Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Ketorolac Nasal Spray Pentosan Polysulfate Sodium An increased risk of bleeding Details Ketorolac Nasal Spray Phenindione An increased risk of bleeding Details Ketorolac Nasal Spray Phenprocoumon An increased risk of bleeding Details Ketorolac Nasal Spray Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Ketorolac Nasal Spray Prasugrel Effient An increased risk of bleeding Details Ketorolac Nasal Spray Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.