Ketorolac Nasal Spray

246 interactions 464 cited references

Also sold as: Sprix Sprix®

About Ketorolac Nasal Spray

Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Etodolac Fepradinol Etofenamate Etoricoxib Felbinac Fenoprofen

64 Contraindicated 129 Major 53 Moderate

All (246) Contraindicated (64) Major (129) Moderate (53)

Moderate

Ketorolac Nasal Spray Acebutolol Sectral® Reduced antihypertensive effect Details Ketorolac Nasal Spray Anisindione An increased risk of bleeding Details Ketorolac Nasal Spray Atenolol Tenormin Reduced antihypertensive effect Details Ketorolac Nasal Spray Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Betaxolol Betoptic S Reduced antihypertensive effect Details Ketorolac Nasal Spray Bisoprolol Zebeta® Reduced antihypertensive effect Details Ketorolac Nasal Spray Candesartan Atacand Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Carteolol Reduced antihypertensive effect Details Ketorolac Nasal Spray Carvedilol Coreg Reduced antihypertensive effect Details Ketorolac Nasal Spray Celiprolol Reduced antihypertensive effect Details Ketorolac Nasal Spray Ciprofloxacin An increased risk of convulsions Details Ketorolac Nasal Spray Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Ketorolac Nasal Spray Dicumarol An increased risk of bleeding Details Ketorolac Nasal Spray Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Enalaprilat Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Esmolol Brevibloc Reduced antihypertensive effect Details Ketorolac Nasal Spray Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Ginkgo An increased risk of bleeding Details Ketorolac Nasal Spray Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Labetalol Normodyne® Reduced antihypertensive effect Details Ketorolac Nasal Spray Levobunolol Betagan Reduced antihypertensive effect Details Ketorolac Nasal Spray Levofloxacin Levaquin An increased risk of seizures Details Ketorolac Nasal Spray Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray L-Methylfolate Decreased l-methylfolate efficacy Details Ketorolac Nasal Spray Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Ma Huang Increased risk of developing gastric mucosal lesions Details Ketorolac Nasal Spray Metipranolol Reduced antihypertensive effect Details Ketorolac Nasal Spray Metoprolol Kapspargo Reduced antihypertensive effect Details Ketorolac Nasal Spray Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Nadolol Corgard Reduced antihypertensive effect Details Ketorolac Nasal Spray Nebivolol Bystolic Reduced antihypertensive effect Details Ketorolac Nasal Spray Norfloxacin An increased risk of seizures Details Ketorolac Nasal Spray Ofloxacin Floxin® An increased risk of seizures Details Ketorolac Nasal Spray Olmesartan Benicar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Oxprenolol Reduced antihypertensive effect Details Ketorolac Nasal Spray Penbutolol Levatol® Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.