Ketorolac Nasal Spray

246 interactions 464 cited references
Also sold as: Sprix Sprix®
About Ketorolac Nasal Spray

Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Etodolac Fepradinol Etofenamate Etoricoxib Felbinac Fenoprofen
64 Contraindicated 129 Major 53 Moderate
All (246) Contraindicated (64) Major (129) Moderate (53)

Major

Ketorolac Nasal Spray Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Protein C Ceprotin An increased risk of bleeding Details Ketorolac Nasal Spray Protriptyline An increased risk of bleeding Details Ketorolac Nasal Spray Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Reviparin An increased risk of bleeding Details Ketorolac Nasal Spray Rivaroxaban Xarelto An increased risk of bleeding Details Ketorolac Nasal Spray Selexipag Uptravi An increased risk of bleeding Details Ketorolac Nasal Spray Sertraline An increased risk of bleeding Details Ketorolac Nasal Spray Sibutramine An increased risk of bleeding Details Ketorolac Nasal Spray Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Nasal Spray Sulfinpyrazone An increased risk of bleeding Details Ketorolac Nasal Spray Sulodexide An increased risk of bleeding Details Ketorolac Nasal Spray Tacrolimus Astagraf Acute renal failure Details Ketorolac Nasal Spray Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Ketorolac Nasal Spray Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Ketorolac Nasal Spray Tianeptine An increased risk of bleeding Details Ketorolac Nasal Spray Ticagrelor Brilinta An increased risk of bleeding Details Ketorolac Nasal Spray Ticlopidine Ticlid® An increased risk of bleeding Details Ketorolac Nasal Spray Tinzaparin An increased risk of bleeding Details Ketorolac Nasal Spray Tirofiban An increased risk of bleeding Details Ketorolac Nasal Spray Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Trazodone Raldesy An increased risk of bleeding Details Ketorolac Nasal Spray Treprostinil Orenitram An increased risk of bleeding Details Ketorolac Nasal Spray Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Nasal Spray Trichlormethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Trimipramine An increased risk of bleeding Details Ketorolac Nasal Spray Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Ketorolac Nasal Spray Venlafaxine An increased risk of bleeding Details Ketorolac Nasal Spray Vilazodone Viibryd An increased risk of bleeding Details Ketorolac Nasal Spray Vorapaxar Zontivity An increased risk of bleeding Details Ketorolac Nasal Spray Vortioxetine Trintellix An increased risk of bleeding Details Ketorolac Nasal Spray Warfarin Coumadin An increased risk of bleeding Details Ketorolac Nasal Spray Xipamide Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Ketorolac Nasal Spray Acebutolol Sectral® Reduced antihypertensive effect Details Ketorolac Nasal Spray Anisindione An increased risk of bleeding Details Ketorolac Nasal Spray Atenolol Tenormin Reduced antihypertensive effect Details Ketorolac Nasal Spray Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Betaxolol Betoptic S Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.