Iproniazid

14 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sertraline Opicapone Levodopa Oral Inhalation Entacapone Deutetrabenazine Amitriptyline
7 Contraindicated 7 Major
All (14) Contraindicated (7) Major (7)

Contraindicated

Iproniazid Amitriptyline Elavil Explained Neurotoxicity, seizures, or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Iproniazid Sertraline Explained CNS toxicity or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Iproniazid Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Iproniazid Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Iproniazid Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Iproniazid Levodopa Oral Inhalation Inbrija Hypertensive crisis Details Iproniazid Opicapone Ongentys Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details

Major

Iproniazid Dolasetron Anzemet Increased risk of serotonin syndrome Details Iproniazid Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Iproniazid Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Iproniazid Granisetron Injection Granisol Increased risk of serotonin syndrome Details Iproniazid Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Iproniazid Metoclopramide Injection Gimoti Increased risk of hypertensive crisis Details Iproniazid Metoclopramide Nasal Spray Gimoti Increased risk of hypertensive crisis Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.