Irinotecan Injection and Tedizolid Phosphate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Tedizolid Phosphate
Irinotecan Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased BCRP substrates exposure and an increased risk of BCRP substrates-related adverse reactions
Interaction Deep Dive
Coadministration of tedizolid and BCRP substrates may increase BCRP substrates exposure, which may increase BCRP substrates-related adverse reactions. If possible, consider an interruption in the treatment of the coadministered BCRP substrates during treatment with tedizolid, especially for BCRP substrates with a narrow therapeutic index. If coadministration cannot be avoided, monitor for adverse reactions related to the concomitantly administered BCRP substrates1.
Why it happens (mechanism)
Inhibition of BCRP-mediated efflux transport of tedizolid
Common questions
Can I take Irinotecan Injection and Tedizolid Phosphate together?
Increased BCRP substrates exposure and an increased risk of BCRP substrates-related adverse reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Irinotecan Injection and Tedizolid Phosphate interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Irinotecan Injection or Tedizolid Phosphate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: SIVEXTRO® intravenous injection, oral tablets, tedizolid phosphate intravenous injection, oral tablets. Merck Sharp & Dohme Corp (per FDA), Rahway, NJ, 2026. DailyMed
Keep reading about Tedizolid Phosphate
Keep reading about Irinotecan Injection
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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