Iron

37 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Baloxavir Marboxil Dolutegravir Levodopa Oral Inhalation Levothyroxine
4 Major 31 Moderate 2 Minor
All (37) Major (4) Moderate (31) Minor (2)

Major

Iron Baloxavir Marboxil Xofluza Decreased baloxavir concentration Details Iron Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Reduced dolutegravir exposure and reduced efficacy of dolutegravir Details Iron Levodopa Oral Inhalation Inbrija Potentially reduced carbidopa or levodopa exposure and reduced efficacy of carbidopa/levodopa Details Iron Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details

Moderate

Iron Omeprazole Gastrobim Explained Reduced iron salts absorption Details Iron Alendronate Binosto Reduced bisphosphonate absorption Details Iron Cefdinir Omnicef® Decreased cefdinir efficacy; formation of reddish stools Details Iron Deferiprone Ferriprox Decreased absorption of minerals Details Iron Delafloxacin Baxdela Decreased delafloxacin efficacy Details Iron Delafloxacin Injection Baxdela Decreased delafloxacin efficacy Details Iron Demeclocycline Declomycin® Decreased demeclocycline and iron effectiveness Details Iron Dexlansoprazole Dexilant Reduced iron bioavailability Details Iron Doxycycline Injection Acticlate Decreased tetracycline and iron effectiveness Details Iron Entacapone Comtan Decreased entacapone bioavailability Details Iron Esomeprazole Nexium Reduced iron bioavailability Details Iron Esomeprazole Injection Nexium Reduced iron bioavailability Details Iron Etidronate Didronel® Reduced bisphosphonate absorption Details Iron Gatifloxacin Ophthalmic Zymar® Decreased gatifloxacin effectiveness Details Iron Gemifloxacin Factive Decreased gemifloxacin absorption Details Iron Ibandronate Boniva Reduced bisphosphonate absorption Details Iron Ibandronate Injection Boniva Reduced bisphosphonate absorption Details Iron Lansoprazole Prevacid Reduced iron bioavailability Details Iron Levofloxacin Levaquin Decreased levofloxacin effectiveness Details Iron Levofloxacin Injection Levaquin Decreased levofloxacin effectiveness Details Iron Methyldopa Aldomet® Decreased methyldopa effectiveness Details Iron Minocycline Amzeeq Reduced efficacy of minocycline Details Iron Minocycline Topical Amzeeq Reduced efficacy of minocycline Details Iron Moxifloxacin Avelox Decreased moxifloxacin effectiveness Details Iron Moxifloxacin Injection Avelox Decreased moxifloxacin effectiveness Details Iron Moxifloxacin Ophthalmic Moxeza® Decreased moxifloxacin effectiveness Details Iron Ofloxacin Floxin® Decreased ofloxacin effectiveness Details Iron Ofloxacin Ophthalmic Ocuflox Decreased ofloxacin effectiveness Details Iron Ofloxacin Otic Floxin® Otic Decreased ofloxacin effectiveness Details Iron Omadacycline Nuzyra Decreased effectiveness of omadacycline Details Iron Omadacycline Injection Nuzyra Decreased effectiveness of omadacycline Details

Minor

Iron Chloramphenicol Injection Chloromycetin® Injection Decreased iron effectiveness Details Iron Cholestyramine Resin Locholest® Decreased iron effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.