Islatravir

Name: Islatravir Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

10 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Emtricitabine Lamivudine Cladribine Injection Cladribine Clofarabine Injection Cytarabine

2 Contraindicated 8 Major

All (10) Contraindicated (2) Major (8)

Major

Islatravir Cladribine Injection Leustatin® Reduced islatravir-triphosphate exposure and reduced efficacy of islatravir Details Islatravir Cladribine Mavenclad Reduced islatravir-triphosphate exposure and reduced efficacy of islatravir Details Islatravir Clofarabine Injection Clolar Reduced islatravir-triphosphate exposure and reduced efficacy of islatravir Details Islatravir Cytarabine Cytosar-U® Reduced islatravir-triphosphate exposure and reduced efficacy of islatravir Details Islatravir Fludarabine Injection Fludara® Reduced islatravir-triphosphate exposure and reduced efficacy of islatravir Details Islatravir Gemcitabine Avgemsi Reduced islatravir-triphosphate exposure and reduced efficacy of islatravir Details Islatravir Gemcitabine Injection Avgemsi Reduced islatravir-triphosphate exposure and reduced efficacy of islatravir Details Islatravir Pentostatin Injection Nipent Reduced islatravir-triphosphate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.