Isocarboxazid

57 interactions 6 explained in plain English
Also sold as: Marplan
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Isocarboxazid Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Isocarboxazid Amitriptyline Elavil Explained An increased risk of hypertensive crisis, severe convulsive seizures, coma or circulatory collapse and an increased risk of seroto... Details Isocarboxazid Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Isocarboxazid Albuterol Oral Inhalation Accuneb® Explained An increased risk of hypertension, headache, and related symptoms Details Isocarboxazid Buprenorphine Belbuca Explained An increased risk of CNS depression Details Isocarboxazid Aripiprazole Injection Abilify An increased risk of CNS depression Details Isocarboxazid Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Isocarboxazid Butorphanol Injection Butorphic An increased risk of CNS depression Details Isocarboxazid Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression Details Isocarboxazid Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Isocarboxazid Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Isocarboxazid Chloroprocaine An increased risk of hypotension Details Isocarboxazid Clonidine Transdermal Patch Catapres An increased risk of hypertension, headache, and related symptoms Details Isocarboxazid Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Isocarboxazid Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Isocarboxazid Diazepam Rectal Diastat An increased risk of CNS depression Details Isocarboxazid Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Isocarboxazid Diphenhydramine Injection Banophen An increased risk of CNS depression Details Isocarboxazid Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Isocarboxazid Dobutamine Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Isocarboxazid Dopamine An increased risk of hypertensive crisis (headache, hyperpyrexia, hypertension) Details Isocarboxazid Droxidopa Northera An increased risk of hypertension, headache, and related symptoms Details Isocarboxazid Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Isocarboxazid Esketamine Nasal Spray Spravato An increased risk of CNS depression Details Isocarboxazid Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression Details Isocarboxazid Hydromorphone Injection Dilaudid An increased risk of CNS depression Details Isocarboxazid Hydromorphone Rectal available generically An increased risk of CNS depression Details Isocarboxazid Levodopa Oral Inhalation Inbrija An increased risk of hypertensive crisis Details Isocarboxazid Linezolid Injection Zyvox An increased risk of hypertensive crisis (headache, palpitation, neck stiffness), severe convulsive seizures or circulatory collap... Details Isocarboxazid Maprotiline Ludiomil® An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Isocarboxazid Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Isocarboxazid Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Isocarboxazid Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Isocarboxazid Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Isocarboxazid Midazolam Injection Nayzilam An increased risk of CNS depression Details Isocarboxazid Morphine Injection Astramorph® PF Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Isocarboxazid Nalbuphine Injection Nubain® An increased risk of CNS depression Details Isocarboxazid Opicapone Ongentys Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.