Isocarboxazid and Linezolid Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Isocarboxazid
Linezolid Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of hypertensive crisis (headache, palpitation, neck stiffness), severe convulsive seizures or circulatory collapse
Interaction Deep Dive
Concurrent use of isocarboxazid with another MAOI is contraindicated as it may cause hypertensive crisis, severe convulsive seizures, coma, or circulatory collapse. Wait a minimum of one week after discontinuing an MAOI before initiating therapy with another MAOI. After the one-week, medication-free period, initiate isocarboxazid at one-half the normal starting dosage for at least the first week of therapy1.
Why it happens (mechanism)
Additive monoamine oxidase inhibition
Common questions
Can I take Isocarboxazid and Linezolid Injection together?
An increased risk of hypertensive crisis (headache, palpitation, neck stiffness), severe convulsive seizures or circulatory collapse Always confirm with your pharmacist or prescriber before making any change.
How serious is the Isocarboxazid and Linezolid Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Isocarboxazid or Linezolid Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: MARPLAN oral tablets, isocarboxazid oral tablets. Validus Pharmaceuticals LLC (per Dailymed), Parsippany, NJ, 2023. DailyMed
Keep reading about Isocarboxazid
Keep reading about Linezolid Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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