Isotretinoin

Name: Isotretinoin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

44 interactions 30 explained in plain English 270 cited references

Also sold as: Absorica Absorica® Accutane Accutane® Amnesteem Amnesteem® Claravis Claravis® Myorisan Myorisan® Sotret Sotret® Zenatane Zenatane®

About Isotretinoin

Isotretinoin is a retinoid medication used to treat severe acne that hasn't responded to other treatments like antibiotics. Read the full Isotretinoin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Estradiol Topical Omadacycline Injection Gestodene Etonogestrel Ethynodiol Ethinyl Estradiol

43 Major 1 Moderate

All (44) Major (43) Moderate (1)

Major

Isotretinoin Medroxyprogesterone Injection Depo-Provera Decreased effectiveness of hormonal contraceptives Details Isotretinoin Minocycline Topical Amzeeq An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Omadacycline Injection Nuzyra An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Moderate

Isotretinoin Vitamin A Aquasol A Explained Increased risk of vitamin A toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.