Isotretinoin

44 interactions 30 explained in plain English 270 cited references
Also sold as: Absorica Absorica® Accutane Accutane® Amnesteem Amnesteem® Claravis Claravis® Myorisan Myorisan® Sotret Sotret® Zenatane Zenatane®
About Isotretinoin

Isotretinoin is a retinoid medication used to treat severe acne that hasn't responded to other treatments like antibiotics. Read the full Isotretinoin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Estradiol Topical Omadacycline Injection Gestodene Etonogestrel Ethynodiol Ethinyl Estradiol
43 Major 1 Moderate
All (44) Major (43) Moderate (1)

Major

Isotretinoin Chlortetracycline Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Demeclocycline Declomycin® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Desogestrel Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Dienogest Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Doxycycline Acticlate Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Drospirenone Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Eravacycline Xerava Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Estradiol Delestrogen Decreased effectiveness of hormonal contraceptives Details Isotretinoin Ethinyl Estradiol Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Ethynodiol Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Etonogestrel Nexplanon Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Gestodene Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Levonorgestrel After banger Decreased effectiveness of hormonal contraceptives Details Isotretinoin Lymecycline Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Meclocycline Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Medroxyprogesterone Amen® Decreased effectiveness of hormonal contraceptives Details Isotretinoin Mestranol Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Methacycline Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Minocycline Amzeeq An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Nomegestrol Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Norelgestromin Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Norethindrone Aygestin Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Norgestimate Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Norgestrel Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Omadacycline Nuzyra An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Oxytetracycline Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Palovarotene Sohonos Explained Increased risk of hypervitaminosis A Details Isotretinoin Rolitetracycline Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Sarecycline Seysara Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Segesterone Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Tetracycline Achromycin V® Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Tigecycline Tygacil Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Ulipristal Ella Explained Decreased effectiveness of hormonal contraceptives Details Isotretinoin Valoctocogene Roxaparvovec-Rvox Roctavian Explained Reduced factor VIII activity without ALT elevation Details Isotretinoin Ethanol Explained A disulfiram-like reaction Details Isotretinoin Doxycycline Injection Acticlate An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Eravacycline Injection Xerava An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Isotretinoin Estradiol Topical Divigel Decreased effectiveness of hormonal contraceptives Details Isotretinoin Estradiol Transdermal Patch Alora® Decreased effectiveness of hormonal contraceptives Details Isotretinoin Levonorgestrel Intrauterine System Kyleena Decreased effectiveness of hormonal contraceptives Details

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