Isotretinoin

Name: Isotretinoin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

44 interactions 30 explained in plain English 270 cited references

Also sold as: Absorica Absorica® Accutane Accutane® Amnesteem Amnesteem® Claravis Claravis® Myorisan Myorisan® Sotret Sotret® Zenatane Zenatane®

About Isotretinoin

Isotretinoin is a retinoid medication used to treat severe acne that hasn't responded to other treatments like antibiotics. Read the full Isotretinoin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Estradiol Topical Omadacycline Injection Gestodene Etonogestrel Ethynodiol Ethinyl Estradiol

43 Major 1 Moderate

All (44) Major (43) Moderate (1)

Moderate

Isotretinoin Vitamin A Aquasol A Explained Increased risk of vitamin A toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.