Itraconazole

206 interactions 14 explained in plain English
Also sold as: Sporanox Tolsura
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Itraconazole Ifosfamide Injection Ifex Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Infigratinib Truseltiq Increased infigratinib plasma concentrations Details Itraconazole Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Itraconazole Isradipine DynaCirc® An increased risk of congestive heart failure Details Itraconazole Istradefylline Nourianz Increased istradefylline exposure Details Itraconazole Ixabepilone Injection IXEMPRA Increased ixabepilone exposure and increase in the incidence and severity of adverse reactions Details Itraconazole Ixazomib Ninlaro Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions and an increased risk of QT interval prolon... Details Itraconazole Leniolisib Joenja Increased leniolisib exposure Details Itraconazole Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Itraconazole Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Itraconazole Levofloxacin Levaquin Increased risk of QT interval prolongation Details Itraconazole Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Itraconazole Levonorgestrel After banger Increased levonorgestrel exposure Details Itraconazole Levonorgestrel Intrauterine System Kyleena Increased levonorgestrel exposure Details Itraconazole Linagliptin Tradjenta Increased CYP3A4/P-gp substrate exposure and an increased risk of CYP3A4/P-gp substrate-related adverse effects Details Itraconazole Loperamide Diamode An increased risk of QT interval prolongation, an increased risk of other ventricular arrhythmias, cardiac arrest, an increased lo... Details Itraconazole Loratadine Agistam® Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Lumateperone Caplyta Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Itraconazole Lurbinectedin Injection Zepzelca Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Itraconazole Macitentan Opsumit Increased macitentan exposure Details Itraconazole Maraviroc Selzentry Increased maraviroc exposure Details Itraconazole Mefloquine Lariam® An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Itraconazole Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Itraconazole Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Itraconazole Metronidazole Flagyl An increased risk of QT interval prolongation Details Itraconazole Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Itraconazole Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Itraconazole Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Itraconazole Midostaurin Rydapt Increased midostaurin exposure Details Itraconazole Mirvetuximab Soravtansine-Gynx Injection Elahere Increased unconjugated DM4 exposure and an increased risk of mirvetuximab soravtansine-gynx adverse reactions Details Itraconazole Mitapivat Aqvesme Increased mitapivat exposure and an increased risk of mitapivat-related adverse reactions Details Itraconazole Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Itraconazole Moxifloxacin Avelox Increased risk of QT interval prolongation Details Itraconazole Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Itraconazole Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Itraconazole Nadolol Corgard Increased nadolol exposure and an increased risk of nadolol adverse effects Details Itraconazole Naldemedine Symproic Increased CYP3A4/P-gp substrate exposure and an increased risk of CYP3A4/P-gp substrate-related adverse effects Details Itraconazole Nateglinide Starlix® Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.