Itraconazole
206 interactions 14 explained in plain English
Also sold as:
Sporanox
Tolsura
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Nisoldipine
Disopyramide
Lovastatin
Dihydroergotamine Injection
Finerenone
Irinotecan Lipid Complex Injection
Major
Itraconazole Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Itraconazole Abametapir Explained Increased exposure of CYP3A4 substrate Details Itraconazole Clindamycin ANTIROBE Explained Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Omeprazole Gastrobim Explained Reduced itraconazole exposure, increased omeprazole exposure and an increased risk of omeprazole-related adverse effects Details Itraconazole Amitriptyline Elavil Explained An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Sertraline Explained An increased risk of QT interval prolongation Details Itraconazole Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Itraconazole Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Itraconazole Acalabrutinib Calquence Increased acalabrutinib exposure Details Itraconazole Ado-Trastuzumab Emtansine Injection KADCYLA Increased cytotoxic component DM1 (maytansine derivative) exposure and an increased risk of toxicity Details Itraconazole Aliskiren Tekturna Increased aliskiren exposure Details Itraconazole Alitretinoin Panretin Increased alitretinoin exposure and an increased risk of alitretinoin-related adverse effects Details Itraconazole Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Itraconazole Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Itraconazole Apixaban Eliquis Explained Increased apixaban exposure and an increased risk of bleeding Details Itraconazole Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Itraconazole Aripiprazole Injection Abilify Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Itraconazole Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Itraconazole Asciminib Scemblix Reduced asciminib exposure and reduced efficacy of asciminib Details Itraconazole Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Atogepant Qulipta Increased atogepant exposure Details Itraconazole Avapritinib Ayvakit Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Itraconazole Avatrombopag Doptelet Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Azathioprine Azasan An increased risk of hepatotoxicity Details Itraconazole Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Belumosudil Rezurock Explained Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Betrixaban Bevyxxa® Increased betrixaban exposure and increased risk of bleeding Details Itraconazole Cabergoline Dostinex® Increased cabergoline exposure and an increased risk of cabergoline-related adverse effects Details Itraconazole Atorvastatin Atorvaliq Increased atorvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Itraconazole Cariprazine Vraylar Explained Increased exposure to cariprazine and its active metabolite, didesmethylcariprazine Details Itraconazole Abiraterone Abirtega Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Afatinib Gilotrif Increased exposure of afatinib Details Itraconazole Amlodipine Amvaz® Increased amlodipine exposure and an increased risk of congestive heart failure Details Itraconazole Anagrelide Agrylin Increased risk of QT interval prolongation Details Itraconazole Axitinib Inlyta Increased axitinib exposure Details Itraconazole Beclomethasone Nasal Spray Beconase Increased beclomethasone exposure and an increased risk of beclomethasone-related adverse reactions Details Itraconazole Beclomethasone Oral Inhalation Beclovent® Increased beclomethasone exposure and an increased risk of beclomethasone-related adverse reactions Details Itraconazole Bedaquiline Sirturo Increased bedaquiline exposure and an increased risk of QT interval prolongation Details Itraconazole Bortezomib Boruzu Increased bortezomib exposure and an increased risk of bortezomib-related adverse effects Details Itraconazole Bosutinib Bosulif Increased bosutinib exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.