Itraconazole

206 interactions 14 explained in plain English
Also sold as: Sporanox Tolsura
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nisoldipine Disopyramide Lovastatin Dihydroergotamine Injection Finerenone Irinotecan Lipid Complex Injection
22 Contraindicated 174 Major 10 Moderate
All (206) Contraindicated (22) Major (174) Moderate (10)

Major

Itraconazole Neratinib Nerlynx Increased neratinib exposure and risk of toxicity Details Itraconazole Nevirapine Viramune Reduced itraconazole exposure and reduced efficacy of itraconazole Details Itraconazole Nicardipine Cardene An increased risk of congestive heart failure Details Itraconazole Nifedipine Adalat® Increased NIFEdipine exposure and an increased risk of hypotension, bradycardia, or acute renal injury Details Itraconazole Nimodipine Nimotop An increased risk of congestive heart failure Details Itraconazole Nintedanib Ofev Increased nintedanib exposure and an increased risk of nintedanib-related adverse effects Details Itraconazole Octreotide Bynfezia An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Octreotide Injection Bynfezia An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Ofloxacin Floxin® An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Olaparib Lynparza Increased olaparib exposure Details Itraconazole Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Itraconazole Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.