Ketobemidone

30 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Ketobemidone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Ketobemidone Sertraline Explained An increased risk of serotonin syndrome Details Ketobemidone Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Ketobemidone Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Ketobemidone Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Ketobemidone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Ketobemidone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Ketobemidone Clopidogrel Plavix Reduced efficacy of clopidogrel Details Ketobemidone Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Ketobemidone Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Ketobemidone Esketamine Nasal Spray Spravato Increased risk of sedation Details Ketobemidone Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Ketobemidone Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Ketobemidone Granisetron Injection Granisol Increased risk of serotonin syndrome Details Ketobemidone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Ketobemidone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Ketobemidone Lacosamide Injection Motpoly An increased risk of CNS depression Details Ketobemidone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Ketobemidone Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Ketobemidone Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Ketobemidone Metoclopramide Injection Gimoti Increased risk of CNS depression Details Ketobemidone Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Ketobemidone Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Ketobemidone Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Ketobemidone Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Ketobemidone Nalbuphine Injection Nubain® Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Ketobemidone Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.