Ketoconazole Topical and Dasabuvir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Ketoconazole Topical
Dasabuvir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased dasabuvir concentrations; increased ketoconazole concentrations
Interaction Deep Dive
Concomitant use of dasabuvir (a P-gp substrate) and ketoconazole (a P-gp inhibitor) may result in increased plasma concentration of dasabuvir. Additionally an increase in ketoconazole concentration may occur. When used with dasabuvir, the maximum dose of ketoconazole is 200 mg/day1. Use caution if coadministered and monitor for increased adverse events associated with both agents.
Why it happens (mechanism)
Inhibition of dasabuvir P-gp efflux transport; unknown mechanism
Common questions
Can I take Ketoconazole Topical and Dasabuvir together?
Increased dasabuvir concentrations; increased ketoconazole concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Ketoconazole Topical and Dasabuvir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Ketoconazole Topical or Dasabuvir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VIEKIRA PAK oral tablets, ombitasvir paritaprevir ritonavir oral tablets and dasabuvir oral tablets. AbbVie Inc. (per manufacturer), North Chicago, Il, 2014.
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Keep reading about Dasabuvir
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