Dasabuvir and Nevirapine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nevirapine
Dasabuvir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased dasabuvir exposure and reduced effect
Interaction Deep Dive
Concomitant use of dasabuvir with etravirine or nevirapine is contraindicated. Coadministration of dasabuvir, given in combination with ombitasvir, paritaprevir, and ritonavir, with a CYP3A4 inducer is expected to decrease dasabuvir plasma concentrations and reduce its therapeutic effect1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of ritonavir-boosted dasabuvir
Common questions
Can I take Dasabuvir and Nevirapine together?
Decreased dasabuvir exposure and reduced effect Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dasabuvir and Nevirapine interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dasabuvir or Nevirapine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Exviera oral tablets, dasabuvir oral tablets. AbbVie Ltd (per EMA), Maidenhead, United Kingdom, 2015.
Keep reading about Nevirapine
Keep reading about Dasabuvir
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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