Dasabuvir and Gemfibrozil: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Gemfibrozil
Dasabuvir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased dasabuvir exposure and an increased risk of QT interval prolongation
Interaction Deep Dive
Gemfibrozil is a CYP2C8 inhibitor1 and dasabuvir is a CYP2C8 substrate 2. Concomitant use of dasabuvir and gemfibrozil is contraindicated due to a 10-fold increase in dasabuvir exposure and an increased risk of QT prolongation 123.
Why it happens (mechanism)
Inhibition of CYP2C8-mediated metabolism of dasabuvir
Literature reports
1 report — tap to read
a) Dasabuvir AUC was increased by a ratio of 11.3 and Cmax was increased by a ratio of 2.01 with coadministration of gemfibrozil as a result of inhibition of the CYP2C8-mediated metabolism of dasabuvir by gemfibrozil 1.
Common questions
Can I take Dasabuvir and Gemfibrozil together?
Increased dasabuvir exposure and an increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dasabuvir and Gemfibrozil interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Dasabuvir or Gemfibrozil need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: LOPID(R) oral tablets, gemfibrozil oral tablets. Parke-Davis (per FDA), New York, NY, 2016. DailyMed
- Product Information: VIEKIRA PAK oral tablets, ombitasvir paritaprevir ritonavir oral tablets, dasabuvir oral tablets. AbbVie Inc (per FDA), North Chicago, Il, 2019.
- Product Information: VIEKIRA XR oral extended-release tablets, dasabuvir, ombitasvir, paritaprevir, ritonavir oral extended-release tablets. AbbVie Inc (per manufacturer), North Chicago, IL, 2019.
Keep reading about Gemfibrozil
Keep reading about Dasabuvir
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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