Gemfibrozil and Daprodustat: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Gemfibrozil
Daprodustat
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased daprodustat exposure
Interaction Deep Dive
Concomitant administration of daprodustat with gemfibrozil (strong CYP2C8 inhibitor) is contraindicated due to a marked increase in daprodustat exposure. Concomitant administration of gemfibrozil 600 mg twice a day for 5 days (strong CYP2C8 inhibitor) with a single 100 mg dose of daprodustat on day 4 of gemfibrozil administration resulted in an 18.6-fold increase in AUC(0 to inf) and a 3.9-fold increase in Cmax of daprodustat1.
Why it happens (mechanism)
Inhibition of CYP2C8-mediated metabolism of daprodustat
Literature reports
1 report — tap to read
a) Concomitant administration of gemfibrozil 600 mg twice a day for 5 days (strong CYP2C8 inhibitor) with a single 100 mg dose of daprodustat on day 4 of gemfibrozil administration resulted in an 18.6-fold increase in AUC(0 to inf) and a 3.9-fold increase in Cmax of daprodustat 1.
Common questions
Can I take Gemfibrozil and Daprodustat together?
Increased daprodustat exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Gemfibrozil and Daprodustat interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Gemfibrozil or Daprodustat need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: JESDUVROQ oral tablets, daprodustat oral tablets. GlaxoSmithKline (per FDA), Durham, NC, 2023. DailyMed
Keep reading about Gemfibrozil
Keep reading about Daprodustat
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist