Ketorolac

277 interactions 464 cited references

Also sold as: Acular Acuvail Sprix Toradol®

About Ketorolac

Ketorolac is used to relieve moderately severe pain, usually after surgery. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diclofenac Topical (Actinic Keratosis) Etoricoxib Felbinac Fepradinol Etofenamate Feprazone

72 Contraindicated 146 Major 59 Moderate

All (277) Contraindicated (72) Major (146) Moderate (59)

Contraindicated

Ketorolac Aspirin Acuprin® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding, and/or perforation) and possible increase in... Details Ketorolac Aspirin Rectal Aspirin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding, and/or perforation) and possible increase in... Details Ketorolac Bromfenac Ophthalmic Bromday® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Diclofenac Ophthalmic Voltaren® Eye Drops Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Diclofenac Topical (Actinic Keratosis) Pennsaid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Diclofenac Topical (Arthritis Pain) Pennsaid® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Diclofenac Transdermal Patch Flector Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Etodolac Lodine Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Fenoprofen Fenopron Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Flurbiprofen Ansaid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Flurbiprofen Ophthalmic Ocufen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ibuprofen Addaprin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ketoprofen Actron® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Aceclofenac Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Acemetacin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Amtolmetin Guacil Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Bromfenac Bromsite Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Bufexamac Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Celecoxib Celebrex Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Choline Salicylate Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Clonixin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Dexibuprofen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Dexketoprofen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Diclofenac Aleve Arthritis Pain Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Diflunisal Dolobid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Dipyrone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Droxicam Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Etofenamate Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Etoricoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Felbinac Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Fepradinol Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Feprazone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Floctafenine Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Flufenamic Acid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Indomethacin Indocin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Lornoxicam Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Loxoprofen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Lumiracoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Meclofenamate Meclodium® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Mefenamic Acid Ponstel® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.