Ketorolac Nasal Spray

246 interactions 464 cited references
Also sold as: Sprix Sprix®
About Ketorolac Nasal Spray

Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Ketorolac Nasal Spray Dibenzepin An increased risk of bleeding Details Ketorolac Nasal Spray Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Ketorolac Nasal Spray Dipyridamole Permole® An increased risk of bleeding Details Ketorolac Nasal Spray Dothiepin An increased risk of bleeding Details Ketorolac Nasal Spray Doxepin Prudoxin An increased risk of bleeding Details Ketorolac Nasal Spray Duloxetine An increased risk of bleeding Details Ketorolac Nasal Spray Edoxaban Savaysa An increased risk of bleeding Details Ketorolac Nasal Spray Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Ketorolac Nasal Spray Enoxaparin Lovenox An increased risk of bleeding Details Ketorolac Nasal Spray Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Nasal Spray Epoprostenol Flolan An increased risk of bleeding Details Ketorolac Nasal Spray Eptifibatide An increased risk of bleeding Details Ketorolac Nasal Spray Escitalopram Lexapro An increased risk of bleeding Details Ketorolac Nasal Spray Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Ketorolac Nasal Spray Fluoxetine RECONCILE An increased risk of bleeding Details Ketorolac Nasal Spray Fluvoxamine An increased risk of bleeding Details Ketorolac Nasal Spray Fondaparinux Arixtra An increased risk of bleeding Details Ketorolac Nasal Spray Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Gossypol Increased risk of adverse gastrointestinal effects Details Ketorolac Nasal Spray Heparin An increased risk of bleeding Details Ketorolac Nasal Spray Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Iloprost Aurlumyn An increased risk of bleeding Details Ketorolac Nasal Spray Imipramine An increased risk of bleeding Details Ketorolac Nasal Spray Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Inotersen Increased risk of bleeding Details Ketorolac Nasal Spray Lepirudin An increased risk of bleeding Details Ketorolac Nasal Spray Levomilnacipran An increased risk of bleeding Details Ketorolac Nasal Spray Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Ketorolac Nasal Spray Lofepramine An increased risk of bleeding Details Ketorolac Nasal Spray Meadowsweet Increased risk of bleeding Details Ketorolac Nasal Spray Melitracen An increased risk of bleeding Details Ketorolac Nasal Spray Melphalan Alkeran An increased risk of bleeding Details Ketorolac Nasal Spray Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ketorolac Nasal Spray Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.