Ketorolac Nasal Spray

246 interactions 464 cited references
Also sold as: Sprix Sprix®
About Ketorolac Nasal Spray

Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Etodolac Fepradinol Etofenamate Etoricoxib Felbinac Fenoprofen
64 Contraindicated 129 Major 53 Moderate
All (246) Contraindicated (64) Major (129) Moderate (53)

Moderate

Ketorolac Nasal Spray Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Pindolol Visken® Reduced antihypertensive effect Details Ketorolac Nasal Spray Pralatrexate Increased pralatrexate exposure Details Ketorolac Nasal Spray Propranolol Hemangeol Reduced antihypertensive effect Details Ketorolac Nasal Spray Quinapril Accupril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Ramipril Altace Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Sotalol Betapace Reduced antihypertensive effect Details Ketorolac Nasal Spray Sparsentan Filspari An increased risk of worsening of renal function Details Ketorolac Nasal Spray Spirapril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Telmisartan Micardis Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Timolol Betimol Reduced antihypertensive effect Details Ketorolac Nasal Spray Trandolapril Mavik® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ketorolac Nasal Spray Valsartan Diovan Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.