Ketorolac Nasal Spray

246 interactions 464 cited references

Also sold as: Sprix Sprix®

About Ketorolac Nasal Spray

Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation. Read the full Ketorolac Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Etodolac Fepradinol Etofenamate Etoricoxib Felbinac Fenoprofen

64 Contraindicated 129 Major 53 Moderate

All (246) Contraindicated (64) Major (129) Moderate (53)

Major

Ketorolac Nasal Spray Milnacipran Savella An increased risk of bleeding Details Ketorolac Nasal Spray Nadroparin An increased risk of bleeding Details Ketorolac Nasal Spray Nefazodone An increased risk of bleeding Details Ketorolac Nasal Spray Nortriptyline An increased risk of bleeding Details Ketorolac Nasal Spray Opipramol An increased risk of bleeding Details Ketorolac Nasal Spray Parnaparin An increased risk of bleeding Details Ketorolac Nasal Spray Paroxetine Paxil An increased risk of bleeding Details Ketorolac Nasal Spray Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Ketorolac Nasal Spray Pentosan Polysulfate Sodium An increased risk of bleeding Details Ketorolac Nasal Spray Phenindione An increased risk of bleeding Details Ketorolac Nasal Spray Phenprocoumon An increased risk of bleeding Details Ketorolac Nasal Spray Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Ketorolac Nasal Spray Prasugrel Effient An increased risk of bleeding Details Ketorolac Nasal Spray Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Nasal Spray Protein C Ceprotin An increased risk of bleeding Details Ketorolac Nasal Spray Protriptyline An increased risk of bleeding Details Ketorolac Nasal Spray Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Reviparin An increased risk of bleeding Details Ketorolac Nasal Spray Rivaroxaban Xarelto An increased risk of bleeding Details Ketorolac Nasal Spray Selexipag Uptravi An increased risk of bleeding Details Ketorolac Nasal Spray Sertraline An increased risk of bleeding Details Ketorolac Nasal Spray Sibutramine An increased risk of bleeding Details Ketorolac Nasal Spray Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Nasal Spray Sulfinpyrazone An increased risk of bleeding Details Ketorolac Nasal Spray Sulodexide An increased risk of bleeding Details Ketorolac Nasal Spray Tacrolimus Astagraf Acute renal failure Details Ketorolac Nasal Spray Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Ketorolac Nasal Spray Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Ketorolac Nasal Spray Tianeptine An increased risk of bleeding Details Ketorolac Nasal Spray Ticagrelor Brilinta An increased risk of bleeding Details Ketorolac Nasal Spray Ticlopidine Ticlid® An increased risk of bleeding Details Ketorolac Nasal Spray Tinzaparin An increased risk of bleeding Details Ketorolac Nasal Spray Tirofiban An increased risk of bleeding Details Ketorolac Nasal Spray Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Nasal Spray Trazodone Raldesy An increased risk of bleeding Details Ketorolac Nasal Spray Treprostinil Orenitram An increased risk of bleeding Details Ketorolac Nasal Spray Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.