Ketorolac Ophthalmic

246 interactions 464 cited references

Also sold as: Acular Acular® Acuvail Acuvail®

About Ketorolac Ophthalmic

Ophthalmic ketorolac is used to treat itchy eyes caused by allergies. It also is used to treat swelling and redness (inflammation) that can occur after cataract surgery. Ketorolac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the release of substances that cause… Read the full Ketorolac Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fenoprofen Flurbiprofen Fepradinol Feprazone Floctafenine Flufenamic Acid

64 Contraindicated 129 Major 53 Moderate

All (246) Contraindicated (64) Major (129) Moderate (53)

Contraindicated

Ketorolac Ophthalmic Nimesulide Beta Cyclodextrin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Oxaprozin Coxanto Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Oxyphenbutazone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Parecoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Pentoxifylline Pentoxil® An increased risk of bleeding Details Ketorolac Ophthalmic Phenylbutazone Equi-Phar Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Piketoprofen Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Piroxicam Feldene Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Probenecid Increased ketorolac exposure Details Ketorolac Ophthalmic Proglumetacin Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Propyphenazone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Proquazone Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Rofecoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Salicylic Acid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Salsalate Disalcid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Sodium Salicylate Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Sulfasalazine Azulfidine Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Sulindac Clinoril® Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Sulopenem Increased ketorolac tromethamine exposure Details Ketorolac Ophthalmic Tenoxicam Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Tiaprofenic Acid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Tolfenamic Acid Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Tolmetin Tolectin 600 Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ketorolac Ophthalmic Valdecoxib Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Ketorolac Ophthalmic Abciximab An increased risk of bleeding Details Ketorolac Ophthalmic Acenocoumarol An increased risk of bleeding Details Ketorolac Ophthalmic Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Ophthalmic Amineptine An increased risk of bleeding Details Ketorolac Ophthalmic Amitriptyline Elavil An increased risk of bleeding Details Ketorolac Ophthalmic Amitriptylinoxide An increased risk of bleeding Details Ketorolac Ophthalmic Amoxapine An increased risk of bleeding Details Ketorolac Ophthalmic Anagrelide Agrylin An increased risk of bleeding Details Ketorolac Ophthalmic Apixaban Eliquis An increased risk of bleeding Details Ketorolac Ophthalmic Ardeparin An increased risk of bleeding Details Ketorolac Ophthalmic Argatroban An increased risk of bleeding Details Ketorolac Ophthalmic Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Bemiparin An increased risk of bleeding Details Ketorolac Ophthalmic Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Betrixaban Bevyxxa® An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.