Ketorolac Ophthalmic

246 interactions 464 cited references
Also sold as: Acular Acular® Acuvail Acuvail®
About Ketorolac Ophthalmic

Ophthalmic ketorolac is used to treat itchy eyes caused by allergies. It also is used to treat swelling and redness (inflammation) that can occur after cataract surgery. Ketorolac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the release of substances that cause… Read the full Ketorolac Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fenoprofen Flurbiprofen Fepradinol Feprazone Floctafenine Flufenamic Acid
64 Contraindicated 129 Major 53 Moderate
All (246) Contraindicated (64) Major (129) Moderate (53)

Major

Ketorolac Ophthalmic Bivalirudin Angiomax An increased risk of bleeding Details Ketorolac Ophthalmic Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Ophthalmic Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Cangrelor Kengreal An increased risk of bleeding Details Ketorolac Ophthalmic Certoparin An increased risk of bleeding Details Ketorolac Ophthalmic Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Cilostazol Pletal® An increased risk of bleeding Details Ketorolac Ophthalmic Citalopram Celexa An increased risk of bleeding Details Ketorolac Ophthalmic Clomipramine Anafranil An increased risk of bleeding Details Ketorolac Ophthalmic Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Clopidogrel Plavix An increased risk of bleeding Details Ketorolac Ophthalmic Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Ketorolac Ophthalmic Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Dabigatran Etexilate An increased risk of bleeding Details Ketorolac Ophthalmic Dalteparin Fragmin An increased risk of bleeding Details Ketorolac Ophthalmic Danaparoid An increased risk of bleeding Details Ketorolac Ophthalmic Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Ophthalmic Desipramine Norpramin An increased risk of bleeding Details Ketorolac Ophthalmic Desirudin Iprivask An increased risk of bleeding Details Ketorolac Ophthalmic Desvenlafaxine Pristiq An increased risk of bleeding Details Ketorolac Ophthalmic Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Ketorolac Ophthalmic Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Dibenzepin An increased risk of bleeding Details Ketorolac Ophthalmic Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Ketorolac Ophthalmic Dipyridamole Permole® An increased risk of bleeding Details Ketorolac Ophthalmic Dothiepin An increased risk of bleeding Details Ketorolac Ophthalmic Doxepin Prudoxin An increased risk of bleeding Details Ketorolac Ophthalmic Duloxetine An increased risk of bleeding Details Ketorolac Ophthalmic Edoxaban Savaysa An increased risk of bleeding Details Ketorolac Ophthalmic Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Ketorolac Ophthalmic Enoxaparin Lovenox An increased risk of bleeding Details Ketorolac Ophthalmic Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ketorolac Ophthalmic Epoprostenol Flolan An increased risk of bleeding Details Ketorolac Ophthalmic Eptifibatide An increased risk of bleeding Details Ketorolac Ophthalmic Escitalopram Lexapro An increased risk of bleeding Details Ketorolac Ophthalmic Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Ketorolac Ophthalmic Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.