Kratom
134 interactions 12 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jun 30, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Cetirizine Injection
Hydromorphone Injection
Palonosetron Injection
Esketamine Nasal Spray
Lithium Carbonate
Asenapine Transdermal Patch
Moderate
Kratom Lurbinectedin Injection Zepzelca Increased CYP3A substrate exposure Details Kratom Macitentan Opsumit Increased CYP3A substrate exposure Details Kratom Maraviroc Selzentry Increased CYP3A substrate exposure Details Kratom Midostaurin Rydapt Increased CYP3A substrate exposure Details Kratom Mitapivat Aqvesme Increased CYP3A substrate exposure Details Kratom Naldemedine Symproic Increased CYP3A substrate exposure Details Kratom Naloxegol Movantik Increased CYP3A substrate exposure Details Kratom Nateglinide Starlix® Increased CYP3A substrate exposure Details Kratom Neratinib Nerlynx Increased CYP3A substrate exposure Details Kratom Nevirapine Viramune Increased CYP3A substrate exposure Details Kratom Nifedipine Adalat® Increased CYP3A substrate exposure Details Kratom Nintedanib Ofev Increased CYP3A substrate exposure Details Kratom Nisoldipine Sular Increased CYP3A substrate exposure Details Kratom Olaparib Lynparza Increased CYP3A substrate exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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