L-Methylfolate

30 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

25 Moderate 5 Minor
All (30) Moderate (25) Minor (5)

Moderate

L-Methylfolate Aspirin Acuprin® Decreased l-methylfolate efficacy Details L-Methylfolate Aspirin Rectal Aspirin Decreased l-methylfolate efficacy Details L-Methylfolate Bromfenac Ophthalmic Bromday® Decreased l-methylfolate efficacy Details L-Methylfolate Diclofenac Ophthalmic Voltaren® Eye Drops Decreased l-methylfolate efficacy Details L-Methylfolate Diclofenac Topical (Actinic Keratosis) Pennsaid Decreased l-methylfolate efficacy Details L-Methylfolate Diclofenac Topical (Arthritis Pain) Pennsaid® Decreased l-methylfolate efficacy Details L-Methylfolate Diclofenac Transdermal Patch Flector Decreased l-methylfolate efficacy Details L-Methylfolate Etodolac Lodine Decreased l-methylfolate efficacy Details L-Methylfolate Fenoprofen Fenopron Decreased l-methylfolate efficacy Details L-Methylfolate Flurbiprofen Ansaid Decreased l-methylfolate efficacy Details L-Methylfolate Flurbiprofen Ophthalmic Ocufen Decreased l-methylfolate efficacy Details L-Methylfolate Ibuprofen Addaprin Decreased l-methylfolate efficacy Details L-Methylfolate Ketoprofen Actron® Decreased l-methylfolate efficacy Details L-Methylfolate Ketorolac Acular Decreased l-methylfolate efficacy Details L-Methylfolate Ketorolac Injection Acular Decreased l-methylfolate efficacy Details L-Methylfolate Ketorolac Nasal Spray Sprix Decreased l-methylfolate efficacy Details L-Methylfolate Ketorolac Ophthalmic Acular Decreased l-methylfolate efficacy Details L-Methylfolate Meclofenamate Meclodium® Decreased l-methylfolate efficacy Details L-Methylfolate Mefenamic Acid Ponstel® Decreased l-methylfolate efficacy Details L-Methylfolate Meloxicam Alloxate Decreased l-methylfolate efficacy Details L-Methylfolate Meloxicam Injection Alloxate Decreased l-methylfolate efficacy Details L-Methylfolate Methotrexate Jylamvo Decreased methotrexate and/or l-methylfolate efficacy Details L-Methylfolate Methotrexate Injection Abitrexate® Decreased methotrexate and/or l-methylfolate efficacy Details L-Methylfolate Nabumetone Relafen Decreased l-methylfolate efficacy Details L-Methylfolate Naproxen Aleve Decreased l-methylfolate efficacy Details

Minor

L-Methylfolate Colchicine Colcrys Explained Decreased l-methylfolate serum levels Details L-Methylfolate Cholestyramine Resin Locholest® Decreased l-methylfolate serum levels Details L-Methylfolate Colestipol Colestid Decreased l-methylfolate serum levels Details L-Methylfolate Levodopa Oral Inhalation Inbrija Decreased l-methylfolate serum levels Details L-Methylfolate Pancrelipase Creon® Decreased l-methylfolate serum levels Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.