Drug Interaction Report

Labetalol and Levoketoconazole: Interaction Details

A pharmacist-reviewed analysis of the Labetalol and Levoketoconazole interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Labetalol

Normodyne® Trandate Trandate®
+

Levoketoconazole

Recorlev Recorlev®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 215 documented Labetalol interactions, 54 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased risk of serious hepatotoxicity and drug-induced liver injury

Interaction Deep Dive

Avoid concomitant use of levoketoconazole with hepatotoxic drugs. Concomitant use may increase the risk of hepatotoxicity1.

Why it happens (mechanism)

Unknown

Common questions

Can I take Labetalol and Levoketoconazole together?

Increased risk of serious hepatotoxicity and drug-induced liver injury Always confirm with your pharmacist or prescriber before making any change.

How serious is the Labetalol and Levoketoconazole interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Labetalol or Levoketoconazole need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (1)

  1. Product Information: RECORLEV(R) oral tablets, levoketoconazole oral tablets. Xeris Pharmaceuticals Inc (per FDA), Chicago, IL, 2023. DailyMed
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Labetalol

Keep reading about Labetalol

All Labetalol interactions (215) Labetalol drug information
Also serious with: Methotrexate Methylergonovine Olodaterol Oral Inhalation Melatonin
Levoketoconazole

Keep reading about Levoketoconazole

All Levoketoconazole interactions (185) Levoketoconazole drug information
Also serious with: Oxaliplatin Injection Clindamycin Topical Metronidazole Injection Chloroquine
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Labetalol + Activated Charcoal American Hellebore American Mistletoe Beer Indian Snakeroot Siberian Cocklebur Tyramine Wine + 168 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.