Lacosamide Injection

234 interactions 81 cited references
Also sold as: Motpoly Vimpat Vimpat® I.V.
About Lacosamide Injection

Lacosamide injection is used to control partial onset seizures (seizures that involve only one part of the brain) in adults and children 1 month of age and older who cannot take oral medications. Lacosamide injection is also used in combination with other medications to control primary generalized tonic-clonic seizures… Read the full Lacosamide Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Zotepine Oxymorphone Oxycodone Oxprenolol Oxazepam Orphenadrine
230 Major 4 Moderate
All (234) Major (230) Moderate (4)

Major

Lacosamide Injection Acebutolol Sectral® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Acecainide An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Acepromazine PROMACE An increased risk of CNS depression Details Lacosamide Injection Ajmaline An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Alfentanil An increased risk of CNS depression Details Lacosamide Injection Alprazolam Xanax An increased risk of CNS depression Details Lacosamide Injection Amiodarone Nexterone An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Amitriptyline Elavil An increased risk of PR interval prolongation, AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Amlodipine Amvaz® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Amobarbital Amytal An increased risk of CNS depression Details Lacosamide Injection Anileridine An increased risk of CNS depression Details Lacosamide Injection Apalutamide Erleada Reduced CYP2C19 substrate exposure Details Lacosamide Injection Aprindine An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Aranidipine An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Aripiprazole Abilify An increased risk of CNS depression Details Lacosamide Injection Aripiprazole Lauroxil Aristada An increased risk of CNS depression Details Lacosamide Injection Asenapine Saphris An increased risk of CNS depression Details Lacosamide Injection Atazanavir Reyataz An increased risk of PR interval prolongation, AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Atenolol Tenormin An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Baclofen Fleqsuvy An increased risk of CNS depression Details Lacosamide Injection Benperidol An increased risk of CNS depression Details Lacosamide Injection Benzhydrocodone An increased risk of CNS depression Details Lacosamide Injection Bepridil An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Betaxolol Betoptic S An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Bisoprolol Zebeta® An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Bretylium An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Bromazepam An increased risk of CNS depression Details Lacosamide Injection Buprenorphine Belbuca An increased risk of CNS depression Details Lacosamide Injection Buspirone Bucapsol An increased risk of CNS depression Details Lacosamide Injection Butabarbital An increased risk of CNS depression Details Lacosamide Injection Butorphanol Butorphic An increased risk of CNS depression Details Lacosamide Injection Calcifediol Rayaldee Altered serum levels of calcifediol Details Lacosamide Injection Calcium Oxybate Xywav An increased risk of CNS depression Details Lacosamide Injection Cannabidiol Epidiolex Increased CYP2C19 substrate exposure, an increased risk of CYP2C19 substrate-related adverse reactions, increased risk of CNS depr... Details Lacosamide Injection Cannabis An increased risk of CNS depression Details Lacosamide Injection Carbinoxamine Carbzah An increased risk of CNS depression Details Lacosamide Injection Carisoprodol Soma An increased risk of CNS depression Details Lacosamide Injection Carphenazine An increased risk of CNS depression Details Lacosamide Injection Carteolol An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lacosamide Injection Carvedilol Coreg An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details

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