Lamivudine

Name: Lamivudine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions 207 cited references

Also sold as: Epivir Epivir-HBV® Epivir®

About Lamivudine

Lamivudine (Epivir) is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children 3 months of age and older. Lamivudine (Epivir-HBV) is used to treat hepatitis B infection. Lamivudine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRT… Read the full Lamivudine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Islatravir Cabotegravir Atidarsagene Autotemcel Etuvetidigene Autotemcel Horsetail Orlistat

1 Contraindicated 7 Major

All (8) Contraindicated (1) Major (7)

Contraindicated

Lamivudine Islatravir Reduced islatravir-triphosphate exposure and reduced efficacy of islatravir Details

Major

Lamivudine Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Lamivudine Atidarsagene Autotemcel Lenmeldy Interference with the manufacturing of atidarsagene autotemcel Details Lamivudine Etuvetidigene Autotemcel An increased risk of interference with the manufacturing of etuvetidigene autotemcel Details Lamivudine Horsetail Reduced lamivudine efficacy; increased HIV RNA viral loads Details Lamivudine Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details Lamivudine Sorbitol Reduced lamivudine exposure, reduced efficacy of lamivudine and loss of virological control Details Lamivudine Tacrolimus Astagraf An increased risk of nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.