Lansoprazole with Velpatasvir Interaction Details
Brand Names Associated with Lansoprazole
- Lansoprazole
- Prevacid®
- Prevacid® 24HR
- Prevacid® NapraPAC® (as a combination product containing Lansoprazole, Naproxen)
- Prevacid® SoluTab®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 17, 2023
Interaction Effect
Decreased velpatasvir exposure
Interaction Summary
Coadministration of velpatasvir and this drug is not recommended as this may result in decreased velpatasvir exposure and a potential loss of efficacy. If concurrent use of a proton pump inhibitor is necessary, omeprazole at a dose not to exceed 20 mg may be given. Administer the combination of sofosbuvir/velpatasvir with food at least 4 hours prior to omeprazole .
Severity
Major
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
Coadministration of velpatasvir and this drug is not recommended as this may result in decreased velpatasvir exposure and a potential loss of efficacy. If concurrent use of a proton pump inhibitor is necessary, omeprazole at a dose not to exceed 20 mg may be given. Administer the combination of sofosbuvir/velpatasvir with food at least 4 hours prior to omeprazole .
Mechanism Of Interaction
Decreased velpatasvir solubility due to pH increases
Literature Reports
A) During pharmacokinetic studies, coadministration of omeprazole 20 mg once daily 2 hours prior to sofosbuvir 400 mg/velpatasvir 100 mg/voxilaprevir 100 mg resulted in a 57% decrease in velpatasvir Cmax and a 54% decrease in AUC. Administration 4 hours after sofosbuvir 400 mg/velpatasvir 100 mg/voxilaprevir 100 mg resulted in a 51% decrease in both velpatasvir Cmax and AUC .
B) During drug interaction studies, coadministration of omeprazole 20 mg simultaneously with velpatasvir 100 mg resulted in a 37% decrease in velpatasvir Cmax and a 36% decrease in AUC. Administration 12 hours prior to velpatasvir resulted in a decrease of 57% and 55%. Administration 2 hours prior to velpatasvir resulted in a 48% decrease and a 38% decrease. Administration 4 hours after velpatasvir resulted in a 33% and 26% decrease .
Lansoprazole Overview
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Prescription lansoprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube between the throat and stomach) in adults and children 1 year of age and older. Prescription lansoprazole is used to treat the damage from GERD in adults and children 1 year of age and older. Prescription lansoprazole is used to allow the esophagus to heal and prevent further damage to the esophagus in adults with GERD. Prescription lansoprazole is also used to treat ulcers (sores in the lining of the stomach or intestine), to prevent more ulcers from developing in adults whose ulcers have already healed, and to decrease the risk that adults who are taking nonsteroidal anti-inflammatory drugs (NSAIDs) will develop ulcers. Prescription lansoprazole is also used to treat conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome in adults. Prescription lansoprazole is also used in combination with other medications to treat and prevent stomach ulcers caused by a certain type of bacteria (H. pylori) in adults. Nonprescription (over-the-counter) lansoprazole is used to treat frequent heartburn (heartburn that occurs two or more days per week) in adults. Lansoprazole is in a class of medications called proton pump inhibitors. It works by decreasing the amount of acid made in the stomach.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.