Lanthanum and Mycophenolate Mofetil: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lanthanum
Mycophenolate Mofetil
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced mycophenolic acid (MPA) exposure and possible reduced efficacy of mycophenolate mofetil
Interaction Deep Dive
Concomitant use of mycophenolate mofetil with sevelamer significantly reduced systemic exposure to the active metabolite, mycophenolic acid (MPA), with single and repeat dosing of sevelamer3. Use of mycophenolate mofetil with calcium-free phosphate binders, such as sevelamer, may reduce mycophenolate mofetil efficacy. Administer calcium-free phosphate binders at least 2 hours after mycophenolate mofetil. Obtaining MPA plasma levels before and after the initiation or discontinuation of concomitant medications may be necessary to ensure MPA levels remain stable 1. In a drug interaction study, concomitant administration of sevelamer and mycophenolate mofetil in adult and pediatric patients decreased the mean MPA Cmax and AUC (0-12h) by 36% and 26%, respectively 2.
Why it happens (mechanism)
Reduced mycophenolate mofetil absorption
Literature reports
2 reports — tap to read
a) AUC(0 to 12 hours) of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, was significantly reduced by a mean of 25%, and the Cmax by 30%, following a single dose of sevelamer in patients with stable renal graft function (n=3 adults, 6 pediatric patients). After 4 days of concomitant use, the AUC was reduced from 69 mcg x hr/mL at baseline to 51 mcg x hr/mL and Cmax was reduced from 22 mcg/mL at baseline to 14 mcg/mL. The mean dose of mycophenolate mofetil was 1300 mg/day and sevelamer was dosed as 1.6 g orally 3 times daily in adults and 1.2 g orally 3 times daily in pediatric patients 3.
b) In a drug interaction study, concomitant administration of sevelamer and mycophenolate mofetil in adult and pediatric patients decreased the mean MPA Cmax and AUC (0-12h) by 36% and 26%, respectively 2.
Common questions
Can I take Lanthanum and Mycophenolate Mofetil together?
Reduced mycophenolic acid (MPA) exposure and possible reduced efficacy of mycophenolate mofetil Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lanthanum and Mycophenolate Mofetil interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Lanthanum or Mycophenolate Mofetil need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: CELLCEPT(R) oral capsules, oral tablets, oral suspension, intravenous injection, mycophenolate mofetil oral capsules, oral tablets, oral suspension, intravenous injection. Genentech USA Inc (per FDA), South San Francisco, CA, 2022. DailyMed
- Product Information: MYHIBBIN oral suspension, mycophenolate mofetil oral suspension. Azurity Pharmaceuticals, Inc.(per Manufacturer), Woburn, MA, 2024. DailyMed
- Pieper AK, Buhle F, Bauer S, et al: The effect of sevelamer on the pharmacokinetics of cyclosporin A and mycophenolate mofetil after renal transplantation. Nephrol Dial Transplant 2004; 19(10):2630-2633. PubMed
Keep reading about Lanthanum
Keep reading about Mycophenolate Mofetil
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