Lasmiditan and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lasmiditan
Cyclosporine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of P-gp substrate and risk of toxicity
Interaction Deep Dive
Lasmiditan inhibits P-gp, as seen in a pharmacokinetic study when coadministration of lasmiditan with dabigatran (P-gp substrate) increased dabigatran exposure by about 25%. Concomitant use of lasmiditan and a P-gp substrate where a small change in substrate plasma concentration may lead to serious toxicities (eg, digoxin) is not recommended1.
Why it happens (mechanism)
Lasmiditan inhibition of P-gp efflux transport
Literature reports
1 report — tap to read
a) In a drug interaction study, coadministration of lasmiditan 200 mg with dabigatran (P-gp substrate) increased dabigatran AUC by 25% and Cmax by 22% compared with dabigatran alone 1.
Common questions
Can I take Lasmiditan and Cyclosporine Injection together?
Increased exposure of P-gp substrate and risk of toxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lasmiditan and Cyclosporine Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Lasmiditan or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: REYVOW(R) oral tablets, lasmiditan oral tablets. Lilly USA LLC (per DailyMed), Indianapolis, IN, 2022. DailyMed
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