Lasmiditan

27 interactions 6 explained in plain English

Also sold as: Reyvow

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Lithium Carbonate Hydromorphone Injection Palonosetron Injection Dolasetron Injection Loperamide

1 Contraindicated 26 Major

All (27) Contraindicated (1) Major (26)

Contraindicated

Lasmiditan Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details

Major

Lasmiditan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Amitriptyline Elavil Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Sertraline Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Buprenorphine Belbuca Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Relugolix Orgovyx Explained Increased relugolix exposure Details Lasmiditan Butorphanol Injection Butorphic Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Cyclosporine Injection Atopica Increased exposure of P-gp substrate and risk of toxicity Details Lasmiditan Cyclosporine Ophthalmic Cequa Increased exposure of P-gp substrate and risk of toxicity Details Lasmiditan Digoxin Cardoxin® Increased exposure of P-gp substrate and risk of toxicity Details Lasmiditan Dolasetron Anzemet Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Dolasetron Injection Anzemet Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Lasmiditan Everolimus Afinitor Increased exposure of P-gp substrate and risk of toxicity Details Lasmiditan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Granisetron Injection Granisol Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Hydromorphone Rectal available generically Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Lasmiditan Linezolid Injection Zyvox Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Lithium Carbonate Lithobid Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Lasmiditan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Lasmiditan Palonosetron Injection Aloxi® Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details

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