Ledipasvir
13 interactions 1 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Ledipasvir Omeprazole Gastrobim Explained Decreased ledipasvir exposure and loss of efficacy Details Ledipasvir Atorvastatin Atorvaliq Increased atorvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Ledipasvir Capmatinib Tabrecta Increased P-gp substrate exposure and an increased risk of increased adverse reactions Details Ledipasvir Dexlansoprazole Dexilant Decreased ledipasvir exposure and loss of efficacy Details Ledipasvir Digoxin Cardoxin® Increased digoxin exposure Details Ledipasvir Esomeprazole Nexium Decreased ledipasvir exposure and loss of efficacy Details Ledipasvir Esomeprazole Injection Nexium Decreased ledipasvir exposure and loss of efficacy Details Ledipasvir Famotidine Calmicid Decreased ledipasvir exposure and loss of efficacy Details Ledipasvir Famotidine Injection Calmicid Decreased ledipasvir exposure and loss of efficacy Details Ledipasvir Lansoprazole Prevacid Decreased ledipasvir exposure and loss of efficacy Details Ledipasvir Lenacapavir Injection Sunlenca Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Ledipasvir Lenacapavir Oral Sunlenca Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse reactions Details Ledipasvir Nizatidine Axid® Decreased ledipasvir exposure and loss of efficacy DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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