Lenvatinib

254 interactions 343 cited references

Also sold as: Lenvima Lenvima®

About Lenvatinib

Lenvatinib is used to treat a certain type of thyroid cancer that has returned or that has spread to other parts of the body and cannot be treated with radioactive iodine. Lenvatinib is also used along with everolimus (Afinitor, Zortress) to treat renal cell carcinoma (RCC, a type of cancer that begins in the kidney) i… Read the full Lenvatinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Smallpox Monkeypox Vaccine Saquinavir Rubella Virus Vaccine, Live Sparfloxacin Piperaquine

21 Contraindicated 232 Major 1 Moderate

All (254) Contraindicated (21) Major (232) Moderate (1)

Contraindicated

Lenvatinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Lenvatinib Bepridil An increased risk of QT interval prolongation Details Lenvatinib Cisapride Propulsid® Increased risk of QT interval prolongation Details Lenvatinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Lenvatinib Dronedarone Multaq Increased risk of QT interval prolongation Details Lenvatinib Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Lenvatinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Lenvatinib Mesoridazine An increased risk of QT interval prolongation Details Lenvatinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Lenvatinib Pimozide An increased risk of QT interval prolongation Details Lenvatinib Piperaquine An increased risk of QT interval prolongation Details Lenvatinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Lenvatinib Saquinavir An increased risk of QT interval prolongation Details Lenvatinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Lenvatinib Sparfloxacin An increased risk of QT interval prolongation Details Lenvatinib Terfenadine An increased risk of QT interval prolongation Details Lenvatinib Thioridazine An increased risk of QT interval prolongation Details Lenvatinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Lenvatinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Lenvatinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details Lenvatinib Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Lenvatinib Amitriptyline Elavil Increased risk of QT-interval prolongation Details Lenvatinib Sertraline Increased risk of QT-interval prolongation Details Lenvatinib Buprenorphine Belbuca Increased risk of QT-interval prolongation Details Lenvatinib Relugolix Orgovyx Increased risk of QT interval prolongation Details Lenvatinib Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Lenvatinib Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation Details Lenvatinib Aripiprazole Injection Abilify Increased risk of QT-interval prolongation Details Lenvatinib Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation Details Lenvatinib Asenapine Transdermal Patch Secuado Increased risk of QT-interval prolongation Details Lenvatinib Azithromycin AzaSite Increased risk of QT-interval prolongation Details Lenvatinib Alfuzosin UroXatral Increased risk of QT-interval prolongation Details Lenvatinib Anagrelide Agrylin Increased risk of QT-interval prolongation Details Lenvatinib Bedaquiline Sirturo Increased risk of QT-interval prolongation Details Lenvatinib Chloroquine Aralen® Increased risk of QT-interval prolongation Details Lenvatinib Dasatinib Phyrago Increased risk of QT-interval prolongation Details Lenvatinib Degarelix Injection Firmagon Increased risk of QT-interval prolongation Details Lenvatinib Deutetrabenazine Austedo Increased risk of QT-interval prolongation Details Lenvatinib Disopyramide Norpace Increased risk of QT-interval prolongation Details Lenvatinib Dofetilide Tikosyn Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.