Leucovorin Injection

11 interactions 397 cited references
Also sold as: Vykoura Wellcovorin® I.V.
About Leucovorin Injection

Leucovorin injection is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to to treat certain types of cancer. Leucovorin injection is used to treat people who have accidentally received an overdose of methotrexate or similar medications. Leu… Read the full Leucovorin Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Capecitabine Doxifluridine Fluorouracil Glucarpidase Sulfamethoxazole Tegafur
7 Major 4 Moderate
All (11) Major (7) Moderate (4)

Major

Leucovorin Injection Capecitabine Xeloda Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Injection Doxifluridine Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Injection Fluorouracil Adrucil Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Injection Glucarpidase Voraxaze Reduced leucovorin exposure and reduced efficacy of leucovorin Details Leucovorin Injection Sulfamethoxazole Sustain Reduced efficacy of trimethoprim/sulfamethoxazole Details Leucovorin Injection Tegafur Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Injection Trimethoprim Primsol Reduced efficacy of trimethoprim/sulfamethoxazole Details

Moderate

Leucovorin Injection Fosphenytoin Cerebyx Reduced efficacy phenytoin or fosphenytoin (prodrug of phenytoin) and an increased risk or frequency of seizures Details Leucovorin Injection Phenobarbital Fidoquel Reduced efficacy PHENobarbital or primidone (prodrug of PHENobarbital) and an increased risk or frequency of seizures Details Leucovorin Injection Phenytoin Dilantin Reduced efficacy phenytoin or fosphenytoin (prodrug of phenytoin) and an increased risk or frequency of seizures Details Leucovorin Injection Primidone Mysoline Reduced efficacy PHENobarbital or primidone (prodrug of PHENobarbital) and an increased risk or frequency of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.