Leucovorin
13 interactions 397 cited referencesLeucovorin is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Leucovorin is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. Leucovorin is in a cl… Read the full Leucovorin drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Moderate
Leucovorin Fosphenytoin Cerebyx Reduced efficacy phenytoin or fosphenytoin (prodrug of phenytoin) and an increased risk or frequency of seizures Details Leucovorin Phenobarbital Fidoquel Reduced efficacy PHENobarbital or primidone (prodrug of PHENobarbital) and an increased risk or frequency of seizures Details Leucovorin Phenytoin Dilantin Reduced efficacy phenytoin or fosphenytoin (prodrug of phenytoin) and an increased risk or frequency of seizures Details Leucovorin Primidone Mysoline Reduced efficacy PHENobarbital or primidone (prodrug of PHENobarbital) and an increased risk or frequency of seizures DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist