Leucovorin

13 interactions 397 cited references
Also sold as: Vykoura Wellcovorin
About Leucovorin

Leucovorin is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Leucovorin is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. Leucovorin is in a cl… Read the full Leucovorin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Capecitabine Fluorouracil Fluorouracil Injection Fluorouracil Topical Glucarpidase Doxifluridine
9 Major 4 Moderate
All (13) Major (9) Moderate (4)

Major

Leucovorin Capecitabine Xeloda Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Fluorouracil Adrucil Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Fluorouracil Injection Adrucil Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Fluorouracil Topical Carac Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Glucarpidase Voraxaze Reduced leucovorin exposure and reduced efficacy of leucovorin Details Leucovorin Doxifluridine Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Sulfamethoxazole Sustain Reduced efficacy of trimethoprim/sulfamethoxazole Details Leucovorin Tegafur Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Leucovorin Trimethoprim Primsol Reduced efficacy of trimethoprim/sulfamethoxazole Details

Moderate

Leucovorin Fosphenytoin Cerebyx Reduced efficacy phenytoin or fosphenytoin (prodrug of phenytoin) and an increased risk or frequency of seizures Details Leucovorin Phenobarbital Fidoquel Reduced efficacy PHENobarbital or primidone (prodrug of PHENobarbital) and an increased risk or frequency of seizures Details Leucovorin Phenytoin Dilantin Reduced efficacy phenytoin or fosphenytoin (prodrug of phenytoin) and an increased risk or frequency of seizures Details Leucovorin Primidone Mysoline Reduced efficacy PHENobarbital or primidone (prodrug of PHENobarbital) and an increased risk or frequency of seizures Details

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