Levetiracetam Injection

16 interactions 289 cited references
Also sold as: Elepsia Keppra Keppra® Roweepra Spritam
About Levetiracetam Injection

Levetiracetam injection is used alone and along with other medications to control partial-onset seizures (seizures that involve only one part of the brain) in adults, children, and infants 1 month of age who cannot take oral medications. Levetiracetam injection is also used in combination with other medications to trea… Read the full Levetiracetam Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Apixaban Azathioprine Calcifediol Dabigatran Etexilate Mesylate Edoxaban Hydroxychloroquine
12 Major 4 Moderate
All (16) Major (12) Moderate (4)

Major

Levetiracetam Injection Apixaban Eliquis Decreased apixaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Levetiracetam Injection Azathioprine Azasan An increased risk of hepatotoxicity Details Levetiracetam Injection Calcifediol Rayaldee Altered serum levels of calcifediol Details Levetiracetam Injection Dabigatran Etexilate Mesylate Decreased dabigatran exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Levetiracetam Injection Edoxaban Savaysa Decreased edoxaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Levetiracetam Injection Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Levetiracetam Injection Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levetiracetam Injection Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Levetiracetam Injection Methotrexate Jylamvo Increased risk of methotrexate exposure and toxicity Details Levetiracetam Injection Orlistat Alli Reduced efficacy of anticonvulsant Details Levetiracetam Injection Pimozide An increased risk of seizure Details Levetiracetam Injection Rivaroxaban Xarelto Decreased rivaroxaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.