Levetiracetam

Name: Levetiracetam Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

19 interactions 289 cited references

Also sold as: Elepsia Elepsia® XR Keppra Keppra® Keppra® XR Roweepra Spritam Spritam®

About Levetiracetam

Levetiracetam is an anticonvulsant medication used to control various types of seizures in people with epilepsy. Read the full Levetiracetam drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Apixaban Azathioprine Calcifediol Dabigatran Dabigatran Etexilate Methotrexate Injection

15 Major 4 Moderate

All (19) Major (15) Moderate (4)

Moderate

Levetiracetam Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Levetiracetam Carbamazepine Carbatrol Symptoms of carbamazepine toxicity (nystagmus, ataxia, dizziness, double vision) Details Levetiracetam Evening Primrose Reduced anticonvulsant effectiveness Details Levetiracetam Ginkgo Decreased anticonvulsant effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.