Levetiracetam

19 interactions 289 cited references
Also sold as: Elepsia Elepsia® XR Keppra Keppra® Keppra® XR Roweepra Spritam Spritam®
About Levetiracetam

Levetiracetam is an anticonvulsant medication used to control various types of seizures in people with epilepsy. Read the full Levetiracetam drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Apixaban Azathioprine Calcifediol Dabigatran Dabigatran Etexilate Methotrexate Injection
15 Major 4 Moderate
All (19) Major (15) Moderate (4)

Major

Levetiracetam Apixaban Eliquis Decreased apixaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Levetiracetam Azathioprine Azasan An increased risk of hepatotoxicity Details Levetiracetam Calcifediol Rayaldee Altered serum levels of calcifediol Details Levetiracetam Dabigatran Pradaxa® Decreased dabigatran exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Levetiracetam Dabigatran Etexilate Decreased dabigatran exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Levetiracetam Edoxaban Savaysa Decreased edoxaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Levetiracetam Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Levetiracetam Dabigatran Etexilate Mesylate Decreased dabigatran exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Levetiracetam Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levetiracetam Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Levetiracetam Methotrexate Jylamvo Increased risk of methotrexate exposure and toxicity Details Levetiracetam Orlistat Alli Reduced efficacy of anticonvulsant Details Levetiracetam Pimozide An increased risk of seizure Details Levetiracetam Rivaroxaban Xarelto Decreased rivaroxaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Levetiracetam Methotrexate Injection Abitrexate® Increased risk of methotrexate exposure and toxicity Details

Moderate

Levetiracetam Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Levetiracetam Carbamazepine Carbatrol Symptoms of carbamazepine toxicity (nystagmus, ataxia, dizziness, double vision) Details Levetiracetam Evening Primrose Reduced anticonvulsant effectiveness Details Levetiracetam Ginkgo Decreased anticonvulsant effectiveness Details

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