Levobunolol

58 interactions 2 explained in plain English

Also sold as: Betagan

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Albuterol Oral Inhalation Clonidine Transdermal Patch Indacaterol Oral Inhalation Lacosamide Injection Methylergonovine Olodaterol Oral Inhalation

6 Major 52 Moderate

All (58) Major (6) Moderate (52)

Moderate

Levobunolol Acarbose Prandase® Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Levobunolol Aspirin Acuprin® Reduced antihypertensive effect Details Levobunolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Levobunolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Levobunolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Levobunolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Levobunolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Levobunolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Levobunolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Levobunolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Levobunolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Etodolac Lodine Reduced antihypertensive effect Details Levobunolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Fenoprofen Fenopron Reduced antihypertensive effect Details Levobunolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Levobunolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Levobunolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Levobunolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Levobunolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Levobunolol Ibuprofen Addaprin Reduced antihypertensive effect Details Levobunolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Ketoprofen Actron® Reduced antihypertensive effect Details Levobunolol Ketorolac Acular Reduced antihypertensive effect Details Levobunolol Ketorolac Injection Acular Reduced antihypertensive effect Details Levobunolol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Levobunolol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Levobunolol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Liraglutide Injection Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Levobunolol Lixisenatide Injection Adlyxin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.