Levofloxacin Injection

354 interactions 547 cited references

Also sold as: Levaquin Levaquin® I.V.

About Levofloxacin Injection

Levofloxacin injection is used to treat infections such as pneumonia; and kidney, prostate (a male reproductive gland), and skin infections. Levofloxacin injection is also used to prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to ant… Read the full Levofloxacin Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cisapride Dronedarone Thioridazine Terfenadine Sparfloxacin Saquinavir

12 Contraindicated 257 Major 85 Moderate

All (354) Contraindicated (12) Major (257) Moderate (85)

Contraindicated

Levofloxacin Injection Bepridil An increased risk of QT interval prolongation Details Levofloxacin Injection Cisapride Propulsid® Increased risk of QT interval prolongation Details Levofloxacin Injection Dronedarone Multaq Increased risk of QT interval prolongation Details Levofloxacin Injection Levoketoconazole Recorlev An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Levofloxacin Injection Mesoridazine An increased risk of QT interval prolongation Details Levofloxacin Injection Pimozide An increased risk of QT interval prolongation Details Levofloxacin Injection Piperaquine An increased risk of QT interval prolongation Details Levofloxacin Injection Saquinavir An increased risk of QT interval prolongation Details Levofloxacin Injection Sparfloxacin An increased risk of QT interval prolongation Details Levofloxacin Injection Terfenadine An increased risk of QT interval prolongation Details Levofloxacin Injection Thioridazine An increased risk of QT interval prolongation Details Levofloxacin Injection Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Levofloxacin Injection Acarbose Prandase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Injection Acecainide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Levofloxacin Injection Acenocoumarol Increased INR Details Levofloxacin Injection Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Levofloxacin Injection Albiglutide Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Injection Alfuzosin UroXatral Increased risk of QT interval prolongation Details Levofloxacin Injection Alogliptin Nesina Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Levofloxacin Injection Amiodarone Nexterone An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Levofloxacin Injection Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Levofloxacin Injection Amitriptyline Elavil Increased risk of QT interval prolongation Details Levofloxacin Injection Anagrelide Agrylin Increased anagrelide exposure and increased risk of QT interval prolongation Details Levofloxacin Injection Apomorphine Apokyn Increased risk of QT interval prolongation Details Levofloxacin Injection Aripiprazole Abilify An increased risk of QT interval prolongation Details Levofloxacin Injection Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Levofloxacin Injection Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Levofloxacin Injection Artemether An increased risk of QT interval prolongation Details Levofloxacin Injection Asenapine Saphris Increased risk of QT interval prolongation Details Levofloxacin Injection Astemizole Increased risk of QT interval prolongation Details Levofloxacin Injection Atazanavir Reyataz Increased risk of QT interval prolongation Details Levofloxacin Injection Atorvastatin Atorvaliq An increased risk of myopathy or rhabdomyolysis Details Levofloxacin Injection Azathioprine Azasan An increased risk of hepatotoxicity Details Levofloxacin Injection Azithromycin AzaSite Increased risk of QT interval prolongation Details Levofloxacin Injection Bedaquiline Sirturo Increased risk of QT interval prolongation Details Levofloxacin Injection Betamethasone Betavet An increased risk of tendon rupture Details Levofloxacin Injection Bretylium An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Levofloxacin Injection Budesonide Entocort An increased risk of tendon rupture Details Levofloxacin Injection Buprenorphine Belbuca An increased risk of QT interval prolongation Details Levofloxacin Injection Bupropion Aplenzin Increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.