Levofloxacin

406 interactions 547 cited references

Also sold as: Levaquin Levaquin®

About Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections. Read the full Levofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Piperaquine Saquinavir Pimozide Mesoridazine Terfenadine Sparfloxacin

12 Contraindicated 297 Major 97 Moderate

All (406) Contraindicated (12) Major (297) Moderate (97)

Moderate

Levofloxacin Aspirin Acuprin® An increased risk of seizures Details Levofloxacin Aspirin Rectal Aspirin An increased risk of seizures Details Levofloxacin Bromfenac Ophthalmic Bromday® An increased risk of seizures Details Levofloxacin Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of seizures Details Levofloxacin Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of seizures Details Levofloxacin Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of seizures Details Levofloxacin Diclofenac Transdermal Patch Flector An increased risk of seizures Details Levofloxacin Didanosine Videx® Decreased levofloxacin effectiveness Details Levofloxacin Etodolac Lodine An increased risk of seizures Details Levofloxacin Fenoprofen Fenopron An increased risk of seizures Details Levofloxacin Flurbiprofen Ansaid An increased risk of seizures Details Levofloxacin Flurbiprofen Ophthalmic Ocufen An increased risk of seizures Details Levofloxacin Ibuprofen Addaprin An increased risk of seizures Details Levofloxacin Ketoprofen Actron® An increased risk of seizures Details Levofloxacin Ketorolac Acular An increased risk of seizures Details Levofloxacin Ketorolac Injection Acular An increased risk of seizures Details Levofloxacin Ketorolac Nasal Spray Sprix An increased risk of seizures Details Levofloxacin Ketorolac Ophthalmic Acular An increased risk of seizures Details Levofloxacin Lanthanum Fosrenol® Reduced bioavailability of quinolone antibiotics Details Levofloxacin Aceclofenac An increased risk of seizures Details Levofloxacin Acemetacin An increased risk of seizures Details Levofloxacin Aluminum Carbonate, Basic Decreased oral levofloxacin effectiveness Details Levofloxacin Aluminum Hydroxide AlternaGEL® Decreased oral levofloxacin effectiveness Details Levofloxacin Aluminum Phosphate Decreased oral levofloxacin effectiveness Details Levofloxacin Aminolevulinic Acid Increased risk of phototoxic skin reaction (ie, severe sunburn) Details Levofloxacin Amtolmetin Guacil An increased risk of seizures Details Levofloxacin Bromfenac Bromsite An increased risk of seizures Details Levofloxacin Bufexamac An increased risk of seizures Details Levofloxacin Calcium Decreased oral levofloxacin effectiveness Details Levofloxacin Celecoxib Celebrex An increased risk of seizures Details Levofloxacin Choline Salicylate An increased risk of seizures Details Levofloxacin Clonixin An increased risk of seizures Details Levofloxacin Dandelion Decreased fluoroquinolone effectiveness Details Levofloxacin Dexibuprofen An increased risk of seizures Details Levofloxacin Dexketoprofen An increased risk of seizures Details Levofloxacin Diclofenac Aleve Arthritis Pain An increased risk of seizures Details Levofloxacin Diflunisal Dolobid An increased risk of seizures Details Levofloxacin Dihydroxyaluminum Aminoacetate Decreased oral levofloxacin effectiveness Details Levofloxacin Dihydroxyaluminum Sodium Carbonate Decreased oral levofloxacin effectiveness Details Levofloxacin Dipyrone An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.